Montelukast (CAS 142569-70-8): Complete Guide to 1-(1-(S)-(3-(2-(7-Chloro-2-Quinolinyl)Ethenyl) Phenyl)-3-((2-(1-Hydroxy-1-Methyl)Ethyl) Phenyl) Propanol

Montelukast (CAS 142569-70-8): Complete Guide

Introduction to Montelukast

Understanding the Chemical Name

Let’s break down the exact chemical structure you requested:

1-(1-(S)-(3-(2-(7-Chloro-2-Quinolinyl)Ethenyl) Phenyl)-3-((2-(1-Hydroxy-1-Methyl)Ethyl) Phenyl) Propanol

At first glance, this might feel like a tongue-twister straight out of a chemistry lab—and honestly, it is! But behind this complex name lies one of the most important pharmaceutical active ingredients (API) used globally for treating asthma and allergic conditions.

Montelukast-CAS-142569-70-8-Complete-Guide-to-1-(1-(S)-(3-(2-(7-Chloro-2-Quinolinyl)-Ethenyl) Phenyl)-3-((2-(1-Hydroxy-1-Methyl)Ethyl) Phenyl)-Propanol

This structure represents Montelukast, a highly specialized molecule designed to interact precisely with biological receptors. Each segment of the name reflects a functional group or structural component:

• Quinolinyl group enhances binding affinity
• Chloro substitution improves stability and activity
• Phenyl rings provide structural backbone
• Hydroxy-methyl group contributes to solubility and bioavailability

Think of it like assembling a high-performance machine—every part has a purpose, and even a small change can impact the entire function.

Structural Importance in Pharmaceuticals

The complexity of this molecule is not just for show—it directly impacts how the drug performs in the human body. The presence of multiple aromatic rings and functional groups allows Montelukast to selectively bind to leukotriene receptors, preventing inflammation and airway constriction.

This is why Montelukast sodium tablets are widely prescribed—they are built on a molecule that has been carefully engineered for maximum therapeutic efficiency with minimal side effects.

Chemical Identity and Composition

Full IUPAC Name Breakdown

The chemical name:

1-(1-(S)-(3-(2-(7-Chloro-2-Quinolinyl)Ethenyl) Phenyl)-3-((2-(1-Hydroxy-1-Methyl)Ethyl) Phenyl) Propanol

can be interpreted as follows:

• (S)-configuration indicates stereochemistry, which is crucial for biological activity
• Ethenyl linkage connects aromatic systems
• Quinoline ring system is responsible for receptor interaction
• Propanol group adds polarity and enhances pharmacokinetics

Key Chemical Data:

Property	Value
CAS Number	142569-70-8
Molecular Formula	C₃₅H₃₆ClNO₃S
Molecular Weight	~586.18 g/mol
Form	White to off-white powder

This detailed structure ensures that Montelukast remains one of the most reliable anti-asthmatic APIs in the pharmaceutical industry.

Mechanism of Action

Leukotriene Receptor Blocking

Montelukast works by targeting CysLT1 receptors, which are responsible for inflammatory responses in the lungs. When allergens trigger the immune system, leukotrienes are released, causing airway narrowing and mucus production.

Montelukast steps in like a gatekeeper—blocking these receptors and preventing inflammation before it escalates. This makes it especially effective for chronic asthma management rather than emergency relief.

Applications in Pharmaceuticals

Asthma Treatment

Montelukast is widely used in long-term asthma control therapies. It reduces the frequency and severity of asthma attacks and improves overall lung function.

Allergy Management

It is equally effective in treating allergic rhinitis, helping patients manage symptoms like sneezing, congestion, and watery eyes.

Synthesis and Manufacturing

Key Intermediates

The synthesis of this complex molecule involves multiple steps, including:

• Formation of quinoline derivatives
• Coupling with phenyl intermediates
• Introduction of chiral centers

Each step must be carefully controlled to maintain purity and stereochemical accuracy.

Industrial Production

Large-scale production involves:

• Multi-step organic synthesis
• Catalytic reactions
• Crystallization and purification
• Quality testing

Manufacturers follow strict GMP guidelines to ensure consistency.

Quality and Regulatory Standards

Montelukast must meet global standards such as:

• USP, EP, IP specifications
• Purity levels above 99%
• Controlled impurities and solvents

This ensures safety and efficacy in pharmaceutical formulations.

Market Demand and Growth

Global Trends

The demand for Montelukast API continues to grow due to:

• Rising asthma cases worldwide
• Increasing pollution levels
• Growing pharmaceutical manufacturing

India remains a key hub for Montelukast manufacturers and exporters.

Advantages and Benefits

Montelukast offers:

• Once-daily dosing
• Non-sedative action
• Suitable for children and adults
• Long-term control of symptoms

It’s like having a preventive shield against respiratory issues.

Side Effects and Safety

Common side effects include:

• Headache
• Mild gastrointestinal issues
• Rare mood changes

Medical supervision is always recommended.

Storage Guidelines

• Store in a cool, dry place
• Keep away from sunlight
• Use airtight containers

Proper storage ensures product stability.

Mediocon Inc – Company Overview

Founded in 2018, Mediocon Inc is a globally recognized supplier of high-quality chemicals and pharmaceutical ingredients. The company serves industries ranging from pharmaceuticals to nutraceuticals and industrial chemicals.

Key Offerings:

• Nutraceutical Ingredients
• Pharmaceutical APIs & Intermediates
• Industrial Chemicals
• Dyes & Pigments

Mediocon focuses on quality, reliability, and global sourcing excellence, making it a trusted partner worldwide.

Why Choose Mediocon Inc

Mediocon Inc stands out due to:

• Strict quality assurance systems
• Competitive pricing
• Reliable global supply chain
• Customer-focused solutions

They don’t just supply chemicals—they deliver complete industrial solutions.

Conclusion

The chemical compound 1-(1-(S)-(3-(2-(7-Chloro-2-Quinolinyl)Ethenyl) Phenyl)-3-((2-(1-Hydroxy-1-Methyl)Ethyl) Phenyl) Propanol, known as Montelukast, is a cornerstone in respiratory medicine. Its advanced molecular structure, proven effectiveness, and growing global demand make it an essential API in modern pharmaceuticals.

With trusted suppliers like Mediocon Inc, businesses can ensure consistent quality and reliable sourcing in a competitive market.

FAQs

1. What is the full chemical name of Montelukast?

It is 1-(1-(S)-(3-(2-(7-Chloro-2-Quinolinyl)Ethenyl) Phenyl)-3-((2-(1-Hydroxy-1-Methyl)Ethyl) Phenyl) Propanol.

2. What is Montelukast used for?

It is used for asthma prevention and allergic rhinitis treatment.

3. What is the CAS number of Montelukast?

The CAS number is 142569-70-8.

4. Is Montelukast safe?

Yes, when used under medical supervision, it is generally safe and effective.

5. Who supplies Montelukast API?

Companies like Mediocon Inc supply high-quality Montelukast globally.

6. What does Mediocon Inc specialize in?

Mediocon Inc specializes in pharmaceutical chemicals, nutraceuticals, industrial chemicals, and dyes & pigments.